Association of High Serum Ferritin Level in Early Pregnancy with Development of Gestational Diabetes Mellitus- A Prospective Observational Study
Published: July 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/49534.15135
Abhijit Das, Shreyasi Karmakar, Sabyasachi Bid, Sudip Kumar Saha
1. Senior Resident, Department of Obstetrics and Gynaecology, ESI-PGIMSR, Esic Medical College, Joka, Kolkata, West Bengal, India.
2. Assistant Professor, Department of Obstetrics and Gynaecology, ESI-PGIMSR, Esic Medical College, Joka, Kolkata, West Bengal, India.
3. Assistant Professor, Department of Anaesthesiology and Critical Care, ESI-PGIMSR, Esic Medical College, Joka, Kolkata, West Bengal, India.
4. Professor, Department of Obstetrics and Gynaecology, IPGME&R/SSKM Hospital, Kolkata, West Bengal, India.
Correspondence
Dr. Shreyasi Karmakar,
Dakshi Apartment, 75, James Long Sarani, Kolkata, West Bengal, India.
E-mail: drshreyasibid@gmail.com
Introduction: Levonadifloxacin is a novel antibiotic belonging to the benzoquinolizine subclass of fluoroquinolone with potent activity against Methicillin Resistant Staphylococcus aureus (MRSA) and Quinolone Resistant Staphylococcus aureus (QRSA). Both intravenous levonadifloxacin and its oral formulation have recently been approved in India for the treatment of acute bacterial skin related infections.
Aim: To assess the activity of levonadifloxacin against gram positive clinical isolates collected from Intensive Care Units (ICUs) using the disk-diffusion method.
Materials and Methods: The present descriptive study where non duplicate isolates of Staphylococcus aureus (S. aureus) and other gram positive isolates from various clinical samples from all Intensive Care Units (ICUs) were collected from June to December 2020 and subjected to levonadifloxacin susceptibility testing (disk diffusion method) as per the Clinical and Laboratory Standards Institute (CLSI) guidelines, 2020. Data analysis was performed using Statistical Package for the Social Sciences (SPSS) software, version 25.0.
Results: A total of 142 gram positive clinical isolates collected from all ICUs of the hospital were analysed. These isolates included coagulase negative S. aureus 109 (76.8%), S. aureus 21 (14.8%) and Enterococcus faecalis 12 (8.4%). All the gram positive isolates of the study were susceptible to levonadifloxacin as per the prespecified interpretive criteria identified based on population pharmacokinetic model and Monte Carlo simulation enabled probability of pharmacodynamic target attainment analysis.
Conclusion: Results of this in vitro study shows good activity of levonadifloxacin against gram positive isolates including difficult to-treat methicillin resistant staphylococcal isolates collected from ICU patients.
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